The Missouri River is unusual because of its two main source regions, one in the high headwaters and one close to the mouth of the river. In this talk, I report the results of research which explored the hydroclimatology of the basin to better understand the climatic controls on the two parts of the basin, the contribution of the snowmelt-driven streamflow to total Missouri River flow, and the nature of droughts in the instrumental record. I will also discuss the first comprehensive set of streamflow reconstructions for the upper Missouri River, and the Turn-of-the-21st Century